Aloe Vera Reference Data

[1] Heggie S, Bryant GP, Tripcony L, Keller J, Rose P, Glendenning M, et al. A Phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs. 2002 Dec;25(6):442-51.
[2] Olsen DL, Raub W, Jr., Bradley C, Johnson M, Macias JL, Love V, et al. The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncol Nurs Forum. 2001 Apr;28(3):543-7.
[3] Williams MS, Burk M, Loprinzi CL, Hill M, Schomberg PJ, Nearhood K, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):345-9.
[4] Kuo PL, Lin TC, Lin CC. The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci. 2002 Sep 6;71(16):1879-92
[5] Zhang L, Tizard IR. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 1996 Nov;35(2):119-28.
[6] Lee JK, Lee MK, Yun YP, Kim Y, Kim JS, Kim YS, et al. Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Int Immunopharmacol. 2001 Jul;1(7):1275-84.
[7] Pugh N, Ross SA, ElSohly MA, Pasco DS. Characterization of Aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem. 2001 Feb;49(2):1030-4.
[8] Lee KH, Kim JH, Lim DS, Kim CH. Anti-leukaemic and anti-mutagenic effects of di(2-ethylhexyl)phthalate isolated from Aloe vera Linne. J Pharm Pharmacol. 2000 May;52(5):593-8.
[9] Yagi A, Kabash A, Okamura N, Haraguchi H, Moustafa SM, Khalifa TI. Antioxidant, free radical scavenging and anti-inflammatory effects of aloesin derivatives in Aloe vera. Planta medica. 2002 Nov;68(11):957-60.
[10] Pigatto PD, Guzzi G. Aloe linked to thyroid dysfunction. Archives of medical research. 2005 Sep-Oct;36(5):608.
[11] Rabe C, Musch A, Schirmacher P, Kruis W, Hoffmann R. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol. 2005 Jan 14;11(2):303-4.

[12] Lee A, Chui PT, Aun CS, Gin T, Lau AS. Possible interaction between sevoflurane and Aloe vera. Ann Pharmacother. 2004 Oct;38(10):1651-4.
[13] Anon. License revoked for aloe vera use. Nat Med Law 1998;1:1-2.
[14] FDA. Status of Certain Additional Over-the-Counter Drug Category II
and III Active Ingredients. http://www.fda.gov/ohrms/dockets/98fr/050902a.htm (Accessed July 25, 2008).
[15] Brinker F. Herb Contraindications and Drug Interactions, 3^rd ed. Sandy (OR): Eclectic Med; 2001.
[16] Robbers JE, et al. Pharmacognosy and pharmacobiotechnology. Baltimore: Williams & Wilkins; 1996.
[17] Foster S, et al. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. New York: Haworth Herbal Press; 1999.
[18] Tyler, V. Herbs of Choice, the Therapeutical Use of Phytomedicinals. Binghamton, New York: Pharmaceutical Press; 1994.

[19] Scientific Articles on Aloe Vera Research: The International Aloe Science Council Scientific Research 

[20] Scientific Book :The Health and Medical Use of Aloe vera by Lawrance G Plaskett, PhD, FRSC 

[21] Scientific Book : Aloe Vera: A Scientific Approach by Robert H Davis, PhD 

[22] Visit the International Aloe Science Council Pages : IASC

[23] Research Paper on the Use of Aloe Vera in Dentistry : Aloe Vera: Its Potential Use in Wound Healing . . . .

[24] J Wound Care. 2004 Apr;13(4):157-8.: Phytotherapy: Use of an aloe vera gel resulted in full healing after treatments such as antibiotics, surgical debridement and skin grafting had failed.

[25] Int Immunopharmacol. 2004 Mar;4(3):411-8.: Mannan has a dual beneficial effect when applied to normal and tumoral cells at the same time by inhibiting the activation of cancer cells and improving that of normal ones.

[26] Oncol Nurs Forum. 2004 Mar-Apr;31(2):237-47. : Prevention & treatment of acute radiation dermatitis

[27] Aliment Pharmacol Ther. 2004 Apr 1;19(7):739-47. :  Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Oral aloe vera taken for 4 weeks produced a clinical response more often than placebo; it also reduced the histological disease activity.

[28] J Med Food. 2004 Spring;7(1):61-6.:  Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. Aloe Vera extract maintained the glucose homeostasis by controlling the carbohydrate metabolizing enzymes.

[29] J Health Care Poor Underserved. 2004 Nov;15(4):576-88.: Attitudes and beliefs among Mexican Americans about type 2 diabetes. Hispanics in the United States have a disproportionately high risk for non-insulin-dependent diabetes mellitus (type 2 diabetes) compared with non-Hispanic whites. Many cited herbal therapies, such as aloe vera (savila) as effective treatments.

[30] Biol Pharm Bull. 2004 May;27(5):694-8. :   Effect of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Aloe gel extract has a protective effect comparable to glibenclamide against hepatotoxicity produced by diabetes if used in the treatment of type-II diabetes.

[31] J Radiat Res (Tokyo). 2004 Sep;45(3):447-54. :  Aloe Polysaccharides Mediated Radioprotective Effect through the Inhibition of Apoptosis. AP improved the 30-day survival rate of mice to 86.0%, from 10.0%. AP exerted radioprotective effects in vitro and in vivo through an inhibition of apoptosis

[32] J Ethnopharmacol. 2004 Jul;93(1):33-7. : The effect of Aloe vera A. Berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. Aloe vera is endowed with gastric acid anti-secretory activity and could protect the gastric mucosa at low concentrations against injurious agents.

[33] J Agric Food Chem. 2004 Sep 8;52(18):5606-11. :  Adsorption behavior of heavy metals on biomaterials of Aloe. Heavy metal removal using biomaterials would be an effective method for the economic treatment of wastewater.

[34] The effect of aloe emodin on the proliferation of a new merkel carcinoma cell line. Aloe emodin, a natural constituent of aloe vera leaves, significantly inhibited the growth of MCC cells. Aloe emodin has been reported to be nontoxic for normal cells but to possess specific toxicity for neuroectodermal tumor cells.

[35] The wound-healing effect of a glycoprotein fraction isolated from aloe vera. It is considered that this glycoprotein fraction is involved in the wound-healing effect of aloe vera via cell proliferation & migration.

[36] Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Acemannan, a major carbohydrate fraction of Aloe vera gel, has been known to have antiviral and antitumoral activities in vivo through activation of immune responses.

[37] Adverse and beneficial effects of plant extracts on skin and skin disorders Beneficial aspects of medicinal plants on skin include: healing of wounds and burn injuries - especially Aloe vera activity against inflammatory/immune disorders affecting skin (e.g. psoriasis); and anti-tumour promoting activity against skin cancer (identified using chemically-induced two-stage carcinogenesis in mice).

[38] Herbal therapy: what every facial plastic surgeon must know. Several herbal medicines, such as aloe vera gel, contain pharmacologically active ingredients that may aid in wound healing.

[40] The effect of aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Patients randomized into the experimental arm of the trial were instructed to liberally apply aloe vera gel to the area at various intervals throughout the day. Over time, there seems to be a protective effect of adding aloe to the soap regimen.

[41] The plant kingdom as a source of anti-ulcer remedies. Aloe gel has been used extensively and their clinical efficacy documented.

[42] Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Aloe-emodin (AE), a hydroxyanthraquinone present in Aloe vera leaves, has a specific in vitro and in vivo antineuroectodermal tumor activity. The growth of human neuroectodermal tumors is inhibited in mice with severe combined immunodeficiency without any appreciable toxic effects on the animals.  AE might represent a conceptually new lead antitumor drug.

[43] nduction of apoptosis in human leukaemic cell lines K562, HL60 and U937 by diethylhexylphthalate isolated from Aloe vera Linne. These results indicate that DEHP isolated from Aloe vera Linne has a potent antileukaemic effect, and thus represents a new type of pharmacological activity with respect to human leukaemic cells.

[44] Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. The healing area of the Aloe vera-treated wound was better than that of the untreated and NSS[NORMAL SALINE SOLUTION]- treated groups during 7 and 14 days after burn. Aloe vera could exhibit the actions of both anti-inflammation and wound healing promotion when applied on a second degree burn wound.

 

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